书籍 Empire of Pain的封面

Empire of Pain

Patrick Radden Keefe

出版社

Doubleday

出版时间

2021-04-13

ISBN

9780385545686

评分

★★★★★

标签

历史

书籍介绍

A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin, by the prize-winning, bestselling author of Say Nothing

The Sackler name adorns the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis.

Empire of Pain begins with the story of three doctor brothers, Raymond, Mortimer and the incalculably energetic Arthur, who weathered the poverty of the Great Depression and appalling anti-Semitism. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. He also had a genius for marketing, especially for pharmaceuticals, and bought a small ad firm.

Arthur devised the marketing for Valium, and built the first great Sackler fortune. He purchased a drug manufacturer, Purdue Frederick, which would be run by Raymond and Mortimer. The brothers began collecting art, and wives, and grand residences in exotic locales. Their children and grandchildren grew up in luxury.

Forty years later, Raymond’s son Richard ran the family-owned Purdue. The template Arthur Sackler created to sell Valium—co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness—was employed to launch a far more potent product: OxyContin. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die.

This is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability. The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful.

Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling. It is a portrait of the excesses of America’s second Gilded Age, a study of impunity among the super elite and a relentless investigation of the naked greed and indifference to human suffering that built one of the world’s great fortunes.

用户评论
Audible听完的,真的是好书,徐徐展开Sackler家族的发迹史,同时也是美国长达20年的鸦片药物起始到泛滥的描绘。Arthur Sackler颠覆了medical advertising,开启了对医疗监管的腐化。之后Richard和他兄弟毫无道德,疯狂敛财,可鄙之极。最后几章却充满无力感,Sackler家族充分利用破产保护,很可能全身而退,难以理解。希望更多人能读到这本书,把Sackler这个名字钉在耻辱柱上。作者的研究非常深入,调查类纪实小说的典范。
这书是豆友“光明小卖部”,临床研究专业人士,强烈推荐给我的。的确好书,大概算investigative journalism的典范了,写这个家族的发迹史,就能记录美国医药营销(面对医疗界和大众两个受众)所有机制从初生到统治性渗透的全过程,还包括对政治和政府部门的影响力渗透,和“黑镜”一样奇幻,如果不是更奇幻的话。我以前看过很多本药厂渗透医疗行业诊断标准的书,这本是最跌宕起伏和魔幻现实主义的。值得一读!说实话,一个医药营销之父开办的药厂,这么多年死守鸦片类止痛药,所有经历都投入在销量,掩盖成瘾和可以被滥用的事实,以及延长专利期,根本无心开发新药,完全就是社会毒瘤,却又是各个大学和艺术博物馆拼死捧住的大慈善家。这才是现实。
即便跻身欧美上流社会,坐拥数百亿美元的财富,身负世界慈善名流家族的名衔,魔鬼就是魔鬼。他们疯狂地攫取暴利、追逐名誉,无情地侵害上百万人的健康,胶割已遭渗漏的社会财富。罔顾社会责任的资本运力,勾连成网,侵蚀美国政府、司法、商业、监管、咨询、科研、学术、社群、公共言论,酿成一场全美范围的毒祸:在过去的20多年里,致使美国50万余人死亡;整整一代人在药物成瘾和继发毒品依赖的深渊挣扎求生;损失2万亿美元,仍无法扑灭鸦片滥用似瘟疫般蔓延。始作俑者正是显赫的Sackler家族。盛名耀目的光环,隐匿、区隔的存在状态,延续三代的行为事实,Keefe紧扣以冲突构成的主线,凭借掘坟一般的调研功力,将分裂的真相曝光于公众视野。也许Sackler家的人以为,并期待,他们的罪行会像因风而起的柳絮如烟。那只是一种断见。
在这个资源有限的零和博弈的世界里,最贪婪最残忍的人才能爬到财富金字塔顶端。黑格尔说“存在即合(乎)理(性)”。
文笔流畅,思路清晰,信息量很大。觉得美国在闹文革的人,一请你们多读书,增长人生见识,二请你们读读这本书。这么罪恶深重极端邪恶的家族,还能玩有钱人的游戏,钻法律的空子,可能全身而退,文革你爹呢?美国需要社会主义,来一点专制不仅不过,非常急需。
Take it with a pinch of salt. No, two pinches of salt.
Some people are addicted to drugs, they are addicted to money
我以為Book 1的stereotypical老白男發家史已經很讓人血壓飆升了,沒想到Book 2&3裡二代三代們的pathological-denial and accountability-avoiding真是歎為觀止的rage-inducing。我相信第一代進入製藥業的出發點是好的,第二代發明oxycontin的出發點是好的。但因為上市前的研究不足,以及aggressive advertising (no thanks to Arthur Sackler and his methods)導致現在opioid crisis這家人的作為 (or lack thereof)肯定是有直接關係的。書裡揭露出有問題的不僅是這家人,不僅是製藥業,不僅是資本,還有不作為的FDA、司法機構和法律漏洞
看得恶向胆边生……真的太气了……就实话讲他们一开始说病人的疼痛不应该被忽视、应该推广对疼痛的治疗的时候我确实很同意,至少这个出发点是没错的,但是可怕的是他们极度aggressive的营销方式,以及东窗事发之后理直气壮地撇清关系……另外我始终觉得医疗行业和教育行业,由于从业者和消费者的信息不对称过于严重,甚至有一些权利上下游倒置的感觉,因此这两个行业的商业化是危险的、自由竞争是不利于消费者的,但是完全依靠(往往underfunded的)公费医疗、公立学校教育又远远不能满足需求,这其中的矛盾实在是很难解决
“ a story about ambition, philanthropy, crime and impunity, the corruption of institutions, power, and greed.“ A masterpiece of nonfiction writing. The roadmap is amazing. Reading it feels like I was immersed in watching all top-picked episodes of Succession, Dopesick and Dark Water without having to use a remote. 有钱能使鬼推磨的完全调查故事