书籍 A Shot to Save the World的封面

A Shot to Save the World

Gregory Zuckerman

出版社

Penguin

出版时间

2021-10-26

ISBN

9780593420393

评分

★★★★★
书籍介绍

Few were ready when a mysterious respiratory illness emerged in Wuhan, China in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response.

It was up to a small group of unlikely and untested scientists and executives to save civilization. A French businessman dismissed by many as a fabulist. A Turkish immigrant with little virus experience. A quirky Midwesterner obsessed with insect cells. A Boston scientist employing questionable techniques. A British scientist despised by his peers. Far from the limelight, each had spent years developing innovative vaccine approaches. Their work was met with skepticism and scorn. By 2020, these individuals had little proof of progress. Yet they and their colleagues wanted to be the ones to stop the virus holding the world hostage. They scrambled to turn their life’s work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough—and to beat each other for the glory that a vaccine guaranteed.

A #1 New York Times bestselling author and award-winning Wall Street Journal investigative journalist lauded for his “bravura storytelling” (Gary Shteyngart) and “first-rate” reporting (The New York Times), Zuckerman takes us inside the top-secret laboratories, corporate clashes, and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It’s a story of courage, genius, and heroism. It’s also a tale of heated rivalries, unbridled ambitions, crippling insecurities, and unexpected drama. A Shot to Save the World is the story of how science saved the world.

作者簡介

古格里‧祖克曼(Gregory Zuckerman)

暢銷書《洞悉市場的人》(The Man Who Solved the Market)、《史上最大交易》(The Greatest Trade Ever)和《頁岩油商》(The Frackers)作者,《華爾街日報》特約撰述,主要報導金融機構、人物專訪、企業等,亦從事避險基金和其他商業調查報導;曾三次贏得財經新聞界最高榮譽的羅布獎(Gerald Loeb award)。

譯者簡介

張玄竺

(序、第一至六章、第十五章)

英國愛丁堡大學英國文學碩士,荷蘭拉德堡大學跨國商業溝通碩士在讀中。從文到商、從東方到西方,人生不斷跨越與挑戰。翻譯既是寄託,也是身心靈的形而上搖滾。

廖月娟

(第七至十章)

美國西雅圖華盛頓大學比較文學碩士。曾獲誠品好讀報告2006年度最佳翻譯人、2007年...

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用户评论
聚焦疫苗研发这场激烈的与时间赛跑 回顾疫情初期不禁心有戚戚焉 总觉得我们还并未越过终点线 从不同的基础研究写起很明智 一方面延展了背景知识的时间轴 另一方面更好地铺垫了迅捷开发测试生产疫苗的先决条件 虽然各位科学家性格各异不乏槽点 整段历程中难免有争议与波折 但确实是科学保卫文明的高亮时刻了!
有意思
Gregory Zuckerman depicted the backstories of 5 COVID vaccines: BioNTech/Pfizer, Moderna, Oxford/AZ, JnJ, and Novavax: years of scientific research, company building and pivoting, epic bravery and execution since the pandemic. Highly recommend!
讲了历史上对疫苗研制有突破性贡献的科研成果,还有相关人物的轶事,半本篇幅在写mRNA是如何在疫苗届咸鱼翻身的,后半部分才是covid疫苗相关的内容,节奏相对快,挺好读的。
2020年的浮出水面,水面下是超过几十年(60年?的基础科学和技术创新的积累,以及像一个漏斗能将地球上人才汇集的地方。
【No.106】超过一半的内容和COVID-19疫苗没什么联系,而在说mRNA疫苗的发展史和相关从业人员的八卦,于是显得副标题过于牵强。相信COVID-19有很多东西可写,但也许不是现在,可能得经过一些时间的沉淀、相关信息的解密以及客观的上帝视角。
疫情期间读新冠疫苗的来龙去脉着实惊心动魄。和CS这种day1演绎性学科相比,生物是个黑暗里摸路的过程(修饰一个核苷就能绕过免疫系统,这也太难想了)。如果没有Karikó这位中年失业,还得过癌症的大龄边缘研究人,靠着贫瘠薪资三十年如一日默默研究mrna,现在也不会有mrna疫苗这种拯救人类的东西,这个世界就是彻底的另一个样子了。 另外书里写到了疫情之初张永振教授的事迹,居功至伟。期待mrna能治疗更多的人类慢性病,也期待Karikó拿诺奖。
非常详细的介绍了几种新型新冠疫苗的源流,比如mRNA疫苗,重组蛋白疫苗,腺病毒疫苗等重要种类,在疫情前,专注于这些新疫苗技术的公司通常是一些小公司,因为疫苗特别是流行性疾病疫苗所针对的疾病很容易就消失(比如非典和中东非典),这些公司没有机会获得资源,他们的生存非常艰难,从事相关研究的科学家的研究也常受冷遇,书中都给了非常详细的介绍。看起来,mRNA疫苗非常有效,并且反应速度会非常快,不仅如此mRNA技术可以用于非常多的疾病的治疗,不仅是用作疫苗,可以用作药物,因为可以直接在身体内产生蛋白质,从各种基因缺陷到癌症(这正是BioNtech早期的研究重点),生物技术又被向前推进了一步。